Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back
MM Bertagnolli - The lancet oncology, 2007 - Elsevier
Chronic inflammation is a tissue-specific process implicated in several diseases of an aging
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX-
2) is a mediator of acute and chronic inflammation, and drugs designed to specifically target
this enzyme have achieved widespread clinical use. Unfortunately, randomised trials of
selective COX-2 inhibitors for cancer prevention have shown that beneficial effects in one
type of tissue can be accompanied by toxic effects in another. These trials documented a …
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX-
2) is a mediator of acute and chronic inflammation, and drugs designed to specifically target
this enzyme have achieved widespread clinical use. Unfortunately, randomised trials of
selective COX-2 inhibitors for cancer prevention have shown that beneficial effects in one
type of tissue can be accompanied by toxic effects in another. These trials documented a …
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